DSPE-PEGs

DSPE-PEGs are a foundational class of amphiphilic conjugates extensively utilized in liposomal drug delivery (e.g., Doxil®), mRNA-LNP formulations, and targeted imaging probes, where the DSPE moiety ensures stable membrane insertion while the PEG chain confers stealth properties. Representative structures such as DSPE-PEGn-CH₂CH₂COOH further incorporate functional terminal groups like carboxyls, enabling ligand conjugation for active targeting and optimized biodistribution—though excessive PEGylation must be balanced to avoid impeding cellular uptake.